PLXNA1

Across TCGA pan-cancer cohorts, PLXNA1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PLXNA1 data layer compared with 11 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher PLXNA1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLXNA1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and SCLC show a favorable association.

MESO, ACC, and KIRC are the cancer types where PLXNA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.245	0.479	<.001	122	view →
ACC	DFS	Median	All	0.200	0.686	<.001	114	view →
KIRC	DFS	Median	II,III,IV	0.445	0.603	.001	96	view →
LIHC	DFS	Tertile	All	0.425	0.600	<.001	87	view →
OV	OS	Median	III,IV	0.264	0.363	.003	46	view →
LUSC	DFS	Quartile	III,IV	0.161	1.000	.001	45	view →
ESCA	OS	Quartile	II,III,IV	0.780	0.338	<.001	42	view →
KICH	DFS	Median	All	0.781	1.000	.002	41	view →
THCA	DFS	Median	II,III,IV	0.633	0.894	.003	32	view →
SCLC	OS	Quartile	II,III,IV	0.943	0.345	<.001	31	view →
DLBC	DFS	Median	IV	1.000	0.223	.001	31	view →
UCS	OS	Median	IV	0.732	0.224	.018	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PLXNA1–MESO (DFS)

Open the MESO breakdown →