PLXNA1

Across TCGA patient cohorts, PLXNA1 mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXNA1-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and PCNA. Each is linked with PLXNA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLXNA1-to-partner and partner-to-PLXNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PLXNA1-low versus PLXNA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNA1→partner) and Y-score (partner→PLXNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.320	+2.104	<.001	.002	3	4
UCEC	4E-BP1 →	+0.305	+1.736	<.001	<.001	3	4
COAD	PCNA →	+0.240	+2.330	.002	<.001	3	4
STAD	RBM15 →	+0.368	+2.321	.026	.005	3	3
STAD	Cyclin-B1 →	+0.413	+2.459	.016	.018	2	4
CESC	Caveolin-1 →	-0.791	-2.321	.006	.031	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

Caspase-7-cleavedD198 by PLXNA1 expression — COAD

Explore this box plot interactively →