PLXNA1

Across TCGA cell cohorts, PLXNA1 mutation is significantly associated with the RNA expression of many other genes, with 1,577 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLXNA1-associated genes across cancer lineages are EIF3L, TTC19, and PTBP2. Each is linked with PLXNA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLXNA1-to-partner and partner-to-PLXNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3L grouped by PLXNA1-low versus PLXNA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNA1→partner) and Y-score (partner→PLXNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF3L →	+0.418	+2.389	.007	.006	3	3
LARGE_INTESTINE	TTC19 →	+0.729	+2.850	<.001	<.001	3	3
LARGE_INTESTINE	PTBP2 →	+0.671	+2.158	.001	.004	3	3
LARGE_INTESTINE	PXMP2 →	+0.517	+2.158	.005	.004	3	3
BLOOD_Leukemia	CDPF1 →	+0.666	+3.228	<.001	.004	3	3
OVARY	MSH4 →	+0.269	+2.570	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,577 associations by consensus.

EIF3L by PLXNA1 expression — LARGE_INTESTINE

Explore this box plot interactively →