PLVAP

Across TCGA cell cohorts, PLVAP mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLVAP-associated genes across cancer lineages are OR1L3, OR1J4, and SMR3A. Each is linked with PLVAP in more than 1 cancer types. Because this analysis shows association rather than direction, both PLVAP-to-partner and partner-to-PLVAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by PLVAP-low versus PLVAP-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLVAP→partner) and Y-score (partner→PLVAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	2
BLOOD_Leukemia	OR1J4 →	+0.143	+3.771	<.001	.004	3	2
LUNG_SCLC	SMR3A →	+0.193	+5.643	<.001	.002	3	1
LUNG_SCLC	OR9G4 →	+0.112	+5.029	<.001	.006	3	1
LUNG_SCLC	KRTAP13-2 →	+0.032	+5.029	<.001	.006	3	1
LUNG_SCLC	OR4F5 →	+0.013	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

OR1L3 by PLVAP expression — SKIN

Explore this box plot interactively →