PLTP

Across TCGA patient cohorts, PLTP protein abundance is significantly associated with the RNA expression of many other genes, with 10,564 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLTP-associated genes across cancer lineages are COLEC12, C1R, and THBS2. Each is linked with PLTP in more than 5 cancer types. Because this analysis shows association rather than direction, both PLTP-to-partner and partner-to-PLTP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLTP versus COLEC12 in BRCA, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLTP→partner) and Y-score (partner→PLTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COLEC12 →	+1.194	+0.524	<.001	<.001	3	6
GBM	C1R →	+1.088	+0.927	<.001	<.001	3	6
COAD	THBS2 →	+2.207	+0.837	<.001	<.001	3	6
GBM	CR1 →	+0.911	+0.623	<.001	<.001	3	6
GBM	TIMP1 →	+1.202	+0.613	<.001	<.001	3	6
COAD	SPP1 →	+2.118	+0.510	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,564 associations by consensus.

PLTP vs COLEC12 — BRCA

Explore this scatter interactively →