PLTP

Across TCGA patient cohorts, PLTP mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLTP-associated genes across cancer lineages are ASNS, ACC_pS79, and JNK_pT183_Y185. Each is linked with PLTP in more than 1 cancer types. Because this analysis shows association rather than direction, both PLTP-to-partner and partner-to-PLTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PLTP-low versus PLTP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLTP→partner) and Y-score (partner→PLTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.515	+2.584	<.001	.010	3	2
UCEC	ACC_pS79 →	+0.295	+1.594	.039	.042	3	1
UCEC	JNK_pT183_Y185 →	-0.165	-3.459	.017	.005	3	1
UCEC	p62 Lck ligand →	+0.337	+2.321	.012	.006	3	1
UCEC	Bcl-2 →	-0.333	-3.302	.020	.010	3	1
UCEC	Bim →	-0.239	-3.000	.027	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ASNS by PLTP expression — UCEC

Explore this box plot interactively →