PLS1

Across TCGA patient cohorts, PLS1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,276 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PLS1-associated genes across cancer lineages are TSPAN1, C1orf210, and SLC44A4. Each is linked with PLS1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PLS1-to-partner and partner-to-PLS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLS1 versus TSPAN1 in UCEC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLS1→partner) and Y-score (partner→PLS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSPAN1 →	+1.854	+0.584	<.001	<.001	3	9
HNSC	C1orf210 →	+1.045	+0.611	<.001	.001	3	8
BRCA	SLC44A4 →	+2.273	+0.515	<.001	<.001	3	8
BRCA	GPR160 →	+0.986	+0.368	<.001	<.001	3	7
CCRCC	OCLN →	+1.015	+0.429	<.001	.001	3	7
UCEC	TJP3 →	+1.408	+0.589	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,276 associations by consensus.

PLS1 vs TSPAN1 — UCEC

Explore this scatter interactively →