PLS1

Across TCGA pan-cancer cohorts, PLS1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PLS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PLS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PLS1 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and LUAD are the cancer types where PLS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−3.042	<.001	11	view →
COAD	Female	All	−1.478	<.001	11	view →
LUAD	Male	II,III,IV	+1.033	<.001	8	view →
BRCA	All	II,III,IV	+0.842	<.001	8	view →
READ	All	All	−1.381	<.001	7	view →
KIRC	All	III,IV	−0.660	<.001	7	view →
UCEC	All	III,IV	+2.873	<.001	6	view →
BLCA	All	III,IV	+1.657	.007	6	view →
LIHC	Male	All	+0.792	<.001	6	view →
STAD	All	All	+1.461	.006	4	view →
CHOL	All	All	+1.719	<.001	3	view →
THCA	Female	II,III,IV	−0.597	.021	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PLS1–KICH

Open the KICH breakdown →