PLS1

Across TCGA patient cohorts, PLS1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLS1-associated genes across cancer lineages are 4E-BP1_pT70, eIF4E, and MEK1. Each is linked with PLS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLS1-to-partner and partner-to-PLS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT70 grouped by PLS1-low versus PLS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLS1→partner) and Y-score (partner→PLS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1_pT70 →	-0.242	-3.442	.007	.005	3	2
UCEC	eIF4E →	+0.162	+2.000	.014	.009	3	2
UCEC	MEK1 →	+0.286	+1.906	.013	.014	3	2
UCEC	Shc_pY317 →	-0.125	-1.502	.009	.027	3	2
UCEC	AR →	-0.278	-1.415	.017	.043	3	2
UCEC	Chk2_pT68 →	-0.141	-2.160	.015	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

4E-BP1_pT70 by PLS1 expression — SKCM

Explore this box plot interactively →