PLS1

Across TCGA cell cohorts, PLS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,063 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLS1-associated GO terms across cancer lineages are Collagen fibril organization, Peptidyl-lysine oxidation, and Extracellular matrix organization. Each is linked with PLS1 in more than 10 cancer types. Because this analysis shows association rather than direction, both PLS1-to-partner and partner-to-PLS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Collagen fibril organization grouped by PLS1-low versus PLS1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLS1→partner) and Y-score (partner→PLS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Collagen fibril organization →	-0.294	-1.466	<.001	<.001	3	11
URINARY_TRACT	Peptidyl-lysine oxidation →	-1.193	-1.338	.001	.003	3	10
SOFT_TISSUE	Extracellular matrix organization →	-0.111	-1.225	.005	.008	3	10
CNS	Melanocyte proliferation →	-1.008	-1.621	<.001	<.001	3	10
LUNG_SCLC	Intestinal hexose absorption →	+0.357	+1.809	<.001	<.001	3	10
URINARY_TRACT	Regulation of cell projection size →	+0.286	+1.751	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,063 associations by consensus.

Collagen fibril organization by PLS1 expression — CNS

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