PLS1

Across TCGA cell cohorts, PLS1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLS1-associated genes across cancer lineages are RAX2, GPR171, and CCL18. Each is linked with PLS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLS1-to-partner and partner-to-PLS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAX2 grouped by PLS1-low versus PLS1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLS1→partner) and Y-score (partner→PLS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RAX2 →	+0.007	+4.108	<.001	.005	3	1
LARGE_INTESTINE	GPR171 →	+0.019	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1
SKIN	RLN3 →	+0.049	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

RAX2 by PLS1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →