PLPP6

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PLPP6 mutation is significantly associated with the RNA expression of many other genes, with 867 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPP6-associated genes across cancer lineages are MDH1P2, RNU6-991P, and MIR5190. Each is linked with PLPP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPP6-to-partner and partner-to-PLPP6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP6→partner) and Y-score (partner→PLPP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LIHCMDH1P2 →+0.102+5.758.005.00332
LIHCRNU6-991P →+0.341+5.033<.001.00932
SKCMMIR5190 →+0.438+5.159<.001.00732
SKCMRN7SL703P →+0.293+5.867<.001.00332
COADPOLR3KP2 →+0.255+4.418<.001.00832
UCECMIR4769 →+0.266+3.027<.001.00732
Each partner links to its Q-omics profile. Showing the 6 strongest of 867 associations by consensus.

Exploration