PLPP5

Across TCGA patient cohorts, PLPP5 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPP5-associated genes across cancer lineages are 14-3-3_beta, JNK_pT183_Y185, and p27_pT157. Each is linked with PLPP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPP5-to-partner and partner-to-PLPP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PLPP5-low versus PLPP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP5→partner) and Y-score (partner→PLPP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.165	-2.973	.002	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.268	-3.156	.003	.020	3	1
UCEC	p27_pT157 →	-0.068	-2.986	.033	.035	3	1
UCEC	Rab11 →	-0.178	-3.169	.025	.020	3	1
UCEC	Annexin-1 →	+0.931	+2.827	.001	.035	3	1
UCEC	Tuberin →	+0.453	+3.009	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

14-3-3_beta by PLPP5 expression — UCEC

Explore this box plot interactively →