PLPP5

Across TCGA pan-cancer cohorts, PLPP5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PLPP5’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PLPP5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLPP5 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

LUAD, BLCA, and LUSC are the cancer types where PLPP5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLPP5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+1.016	<.001	8	view →
BLCA	All	III,IV	+0.805	<.001	8	view →
LUSC	All	II,III,IV	+0.672	<.001	7	view →
KICH	Female	II,III,IV	−1.554	<.001	6	view →
BRCA	All	III,IV	+0.943	<.001	6	view →
UCEC	All	All	+0.863	<.001	6	view →
CHOL	Female	All	+2.416	<.001	5	view →
STAD	All	All	+0.552	<.001	5	view →
LIHC	All	All	+0.498	<.001	4	view →
COAD	All	II,III,IV	+0.464	.002	4	view →
KIRP	Male	All	−0.904	<.001	2	view →
PRAD	All	All	+0.507	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PLPP5–LUAD

Open the LUAD breakdown →