PLPP5

Across TCGA cell cohorts, PLPP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,879 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PLPP5-associated GO terms across cancer lineages are ERAD pathway, Endoplasmic reticulum unfolded protein response, and Response to endoplasmic reticulum stress. Each is linked with PLPP5 in more than 12 cancer types. Because this analysis shows association rather than direction, both PLPP5-to-partner and partner-to-PLPP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERAD pathway grouped by PLPP5-low versus PLPP5-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP5→partner) and Y-score (partner→PLPP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ERAD pathway →	+0.088	+1.198	<.001	<.001	3	13
OESOPHAGUS	Endoplasmic reticulum unfolded protein response →	+0.084	+1.141	.007	.001	3	11
BLOOD_Myeloma	Response to endoplasmic reticulum stress →	+0.086	+1.486	.003	<.001	3	10
BLOOD_Myeloma	Response to topologically incorrect protein →	+0.086	+1.260	.003	.003	3	10
BLOOD_Myeloma	Response to unfolded protein →	+0.096	+1.292	.002	.005	3	10
LUNG_SCLC	Golgi vesicle transport →	+0.064	+1.449	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,879 associations by consensus.

ERAD pathway by PLPP5 expression — LUNG_SCLC

Explore this box plot interactively →