PLPP3

Across TCGA pan-cancer cohorts, PLPP3 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PLPP3 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PLPP3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PLPP3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, COAD, and LSCC are the cancer types where PLPP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.789	0.336	.001	34	view →
COAD	DFS	Median	All	1.000	0.878	.019	30	view →
LSCC	DFS	Tertile	II,III,IV	0.506	0.843	.006	13	view →
PDAC	OS	Tertile	IV	0.973	0.443	.024	9	view →
LUAD	OS	Median	III,IV	0.861	0.384	.030	8	view →
UCEC	OS	Tertile	All	0.864	1.000	.029	6	view →
HNSC	DFS	Median	III,IV	0.879	0.709	.018	6	view →
GBM	DFS	Quartile	All	0.583	0.288	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PLPP3–CCRCC (DFS)

Open the CCRCC breakdown →