PLPP3

Across TCGA pan-cancer cohorts, PLPP3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PLPP3’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PLPP3 RNA is repressed in tumor relative to normal tissue. In most cancer types PLPP3 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and KICH are the cancer types where PLPP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLPP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−2.375	<.001	11	view →
COAD	All	IV	−1.548	<.001	11	view →
KICH	Male	All	−1.170	<.001	10	view →
LUAD	Female	III,IV	−1.402	<.001	9	view →
KIRP	Male	All	−1.286	<.001	9	view →
UCEC	All	All	−1.669	<.001	8	view →
LUSC	All	II,III,IV	−1.506	<.001	8	view →
KIRC	Female	All	+1.041	<.001	8	view →
BRCA	All	All	−1.744	<.001	6	view →
LIHC	Male	All	−0.923	<.001	6	view →
HNSC	Male	All	−0.916	.004	6	view →
CHOL	All	II,III,IV	−2.300	.009	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PLPP3–BLCA

Open the BLCA breakdown →