PLPP3

Across TCGA patient cohorts, PLPP3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPP3-associated genes across cancer lineages are FASN, IGFBP2, and Notch1. Each is linked with PLPP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPP3-to-partner and partner-to-PLPP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PLPP3-low versus PLPP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP3→partner) and Y-score (partner→PLPP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.352	+2.000	.023	.030	3	1
UCEC	IGFBP2 →	-0.833	-3.459	.001	.005	3	1
UCEC	Notch1 →	+0.124	+1.584	.025	.036	3	1
UCEC	p27_pT198 →	+0.092	+2.321	.028	.034	3	1
UCEC	p62 Lck ligand →	+0.364	+1.874	.004	.049	3	1
UCEC	P-Cadherin →	-0.134	-3.321	.018	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

FASN by PLPP3 expression — UCEC

Explore this box plot interactively →