PLPP3

Across TCGA cell cohorts, PLPP3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLPP3-associated genes across cancer lineages are SPRR1A, TMEM114, and MAGEB4. Each is linked with PLPP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPP3-to-partner and partner-to-PLPP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRR1A grouped by PLPP3-low versus PLPP3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP3→partner) and Y-score (partner→PLPP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPRR1A →	+0.287	+5.201	<.001	.006	3	2
BLOOD_Leukemia	TMEM114 →	+0.051	+5.539	<.001	.003	3	1
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	CSN1S1 →	+0.051	+3.347	<.001	.005	3	1
LARGE_INTESTINE	LMNTD1 →	+0.208	+3.554	<.001	.007	3	1
LARGE_INTESTINE	CLDN17 →	+0.042	+3.345	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

SPRR1A by PLPP3 expression — BLOOD_Leukemia

Explore this box plot interactively →