PLPP2

Across TCGA patient cohorts, PLPP2 mutation is significantly associated with the RNA expression of many other genes, with 149 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPP2-associated genes across cancer lineages are LINC01030, MIR4265, and RNU6-1324P. Each is linked with PLPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPP2-to-partner and partner-to-PLPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01030 grouped by PLPP2-low versus PLPP2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP2→partner) and Y-score (partner→PLPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC01030 →	+0.169	+3.584	<.001	.006	3	2
SKCM	MIR4265 →	+0.175	+4.678	<.001	.003	3	2
UCEC	RNU6-1324P →	+0.623	+3.661	<.001	.001	3	2
UCEC	MTATP6P29 →	+0.324	+3.133	<.001	.009	3	2
UCEC	LINC01809 →	+0.202	+3.358	<.001	.006	3	2
UCEC	RN7SL831P →	+0.126	+4.437	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 149 associations by consensus.

LINC01030 by PLPP2 expression — SKCM

Explore this box plot interactively →