PLPP1

Across TCGA patient cohorts, PLPP1 mutation is significantly associated with the RNA expression of many other genes, with 3,391 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPP1-associated genes across cancer lineages are RN7SL785P, RN7SL654P, and MTHFD2P2. Each is linked with PLPP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLPP1-to-partner and partner-to-PLPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL785P grouped by PLPP1-low versus PLPP1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP1→partner) and Y-score (partner→PLPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL785P →	+0.179	+4.376	<.001	.002	3	3
UCEC	RN7SL654P →	+0.085	+2.372	.005	.009	3	3
LGG	MTHFD2P2 →	+0.159	+7.977	<.001	.007	3	2
BLCA	CYP4F36P →	+0.795	+4.558	<.001	.001	3	2
LIHC	MIR455 →	+0.381	+4.567	.005	.004	3	2
LIHC	RNU5F-4P →	+0.272	+4.647	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,391 associations by consensus.

RN7SL785P by PLPP1 expression — BLCA

Explore this box plot interactively →