PLPBP

Across TCGA patient cohorts, PLPBP mutation is significantly associated with the RNA expression of many other genes, with 1,524 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPBP-associated genes across cancer lineages are RNU6-425P, MIR4445, and RNU6-380P. Each is linked with PLPBP in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPBP-to-partner and partner-to-PLPBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-425P grouped by PLPBP-low versus PLPBP-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPBP→partner) and Y-score (partner→PLPBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-425P →	+0.450	+5.588	<.001	.004	3	2
UCEC	MIR4445 →	+0.231	+4.893	<.001	.001	3	2
UCEC	RNU6-380P →	+0.144	+3.885	<.001	.008	3	2
UCEC	COPS8P1 →	+0.083	+2.315	.002	.008	3	1
UCEC	IRF2-DT →	-0.567	-3.678	<.001	.001	3	1
UCEC	DOC2B →	-1.192	-3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,524 associations by consensus.

RNU6-425P by PLPBP expression — BLCA

Explore this box plot interactively →