PLOD3

Across TCGA patient cohorts, PLOD3 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLOD3-associated genes across cancer lineages are p70-S6K, FOXO3a_pS318_S321, and eEF2. Each is linked with PLOD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLOD3-to-partner and partner-to-PLOD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by PLOD3-low versus PLOD3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLOD3→partner) and Y-score (partner→PLOD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	p70-S6K →	+0.510	+3.195	<.001	.010	3	3
LUSC	FOXO3a_pS318_S321 →	-0.145	-3.142	.020	.019	3	2
UCEC	eEF2 →	+0.300	+1.289	.008	.023	3	2
UCEC	A-Raf_pS299 →	-0.107	-3.906	.005	<.001	3	2
UCEC	MEK1 →	+0.371	+3.247	.001	<.001	3	2
UCEC	MSH2 →	-0.260	-2.295	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

p70-S6K by PLOD3 expression — COAD

Explore this box plot interactively →