PLOD3

Across TCGA cell cohorts, PLOD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,313 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PLOD3-associated GO terms across cancer lineages are Protein localization to endoplasmic reticulum, Multi-pass transmembrane protein insertion into ER membrane, and Negative regulation of peptidase activity. Each is linked with PLOD3 in more than 10 cancer types. Because this analysis shows association rather than direction, both PLOD3-to-partner and partner-to-PLOD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to endoplasmic reticulum grouped by PLOD3-low versus PLOD3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLOD3→partner) and Y-score (partner→PLOD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein localization to endoplasmic reticulum →	+0.155	+1.337	<.001	<.001	3	11
BONE	Multi-pass transmembrane protein insertion into ER membrane →	+0.109	+1.084	.005	.007	2	11
CNS	Negative regulation of peptidase activity →	+0.340	+1.456	.007	<.001	3	10
BREAST	Hyaluronan catabolic process →	+0.161	+1.390	<.001	<.001	3	10
KIDNEY	Viral protein processing →	+0.130	+0.808	.001	.009	3	9
BONE	Actin filament depolymerization →	+0.196	+1.033	<.001	.007	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,313 associations by consensus.

Protein localization to endoplasmic reticulum by PLOD3 expression — BONE

Explore this box plot interactively →