PLK3

Across TCGA patient cohorts, PLK3 mutation is significantly associated with the RNA expression of many other genes, with 949 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLK3-associated genes across cancer lineages are CEP19P1, ADAMTS15, and RNA5SP394. Each is linked with PLK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLK3-to-partner and partner-to-PLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP19P1 grouped by PLK3-low versus PLK3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK3→partner) and Y-score (partner→PLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CEP19P1 →	+0.099	+4.251	<.001	.008	3	2
UCEC	ADAMTS15 →	-0.881	-1.991	.006	.009	3	2
CESC	RNA5SP394 →	+0.335	+4.345	<.001	.002	3	2
HNSC	RNU6-1305P →	+0.400	+5.912	<.001	.002	3	2
HNSC	RNU6-116P →	+0.368	+5.303	<.001	.006	3	2
HNSC	RNA5SP229 →	+0.531	+5.069	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 949 associations by consensus.

CEP19P1 by PLK3 expression — COAD

Explore this box plot interactively →