PLK3

Across TCGA pan-cancer cohorts, PLK3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PLK3 data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PLK3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLK3 expression acts as an unfavorable survival marker, although some lineages such as SCLC and SKCM show a favorable association.

ACC, LGG, and LUSC are the cancer types where PLK3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.226	0.648	<.001	91	view →
LGG	DFS	Median	All	0.273	0.518	<.001	54	view →
LUSC	OS	Tertile	All	0.700	0.819	.001	53	view →
MESO	OS	Median	II,III,IV	0.278	0.506	<.001	45	view →
KIRC	DFS	Tertile	IV	0.202	0.453	.004	34	view →
SCLC	DFS	Tertile	All	0.764	0.468	.002	26	view →
DLBC	DFS	Median	All	0.669	0.934	.005	16	view →
PAAD	DFS	Median	All	0.282	0.465	.016	15	view →
SARC	DFS	Median	All	0.434	0.590	.002	14	view →
KIRP	DFS	Tertile	III,IV	0.136	0.745	.026	12	view →
SKCM	OS	Tertile	II,III,IV	0.904	0.826	.008	11	view →
UVM	DFS	Median	III,IV	0.220	0.664	.020	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PLK3–ACC (DFS)

Open the ACC breakdown →