PLK3

Across TCGA patient cohorts, PLK3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLK3-associated genes across cancer lineages are p62 Lck ligand, PCNA, and ERK2. Each is linked with PLK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLK3-to-partner and partner-to-PLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PLK3-low versus PLK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK3→partner) and Y-score (partner→PLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.310	+1.495	.006	.034	3	3
UCEC	PCNA →	+0.169	+2.000	.027	.029	3	3
UCEC	ERK2 →	+0.217	+2.807	.001	.002	3	2
BLCA	PDK1 →	-0.121	-3.169	.038	.019	3	1
UCEC	INPP4B →	-0.249	-1.986	.029	.003	3	1
UCEC	MEK1 →	+0.279	+2.222	.030	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

p62 Lck ligand by PLK3 expression — UCEC

Explore this box plot interactively →