PLK3

Across TCGA cell cohorts, PLK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,712 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLK3-associated GO terms across cancer lineages are Golgi disassembly, Regulation of intracellular protein transport, and DNA damage response, signal transduction by p53 class mediator. Each is linked with PLK3 in more than 14 cancer types. Because this analysis shows association rather than direction, both PLK3-to-partner and partner-to-PLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi disassembly grouped by PLK3-low versus PLK3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK3→partner) and Y-score (partner→PLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Golgi disassembly →	+0.168	+1.494	<.001	<.001	3	15
BONE	Regulation of intracellular protein transport →	+0.071	+1.237	.004	.001	3	13
STOMACH	DNA damage response, signal transduction by p53 class mediator →	+0.097	+1.057	<.001	<.001	3	13
STOMACH	Response to osmotic stress →	+0.070	+0.789	.004	.001	3	11
BONE	Cellular response to environmental stimulus →	+0.050	+1.133	<.001	<.001	3	10
LIVER	Negative regulation of cell cycle G1/S phase transition →	+0.089	+0.953	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,712 associations by consensus.

Golgi disassembly by PLK3 expression — URINARY_TRACT

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