PLK3

Across TCGA cell cohorts, PLK3 mutation is significantly associated with the RNA expression of many other genes, with 108 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLK3-associated genes across cancer lineages are IQCF5, ELOA3DP, and NCMAP. Each is linked with PLK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLK3-to-partner and partner-to-PLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by PLK3-low versus PLK3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLK3→partner) and Y-score (partner→PLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.057	+3.464	<.001	.003	3	2
LARGE_INTESTINE	ELOA3DP →	+0.026	+2.688	<.001	.008	3	2
BLOOD_Leukemia	NCMAP →	+0.024	+3.105	<.001	.005	3	2
BLOOD_Leukemia	PRR23D2 →	+0.205	+3.137	<.001	.009	3	2
URINARY_TRACT	OPRPN →	+0.060	+5.087	<.001	.004	3	1
CNS	NXF5 →	+0.036	+4.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

IQCF5 by PLK3 expression — BLOOD_Leukemia

Explore this box plot interactively →