PLIN4

Across TCGA patient cohorts, PLIN4 mutation is significantly associated with the RNA expression of many other genes, with 3,734 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLIN4-associated genes across cancer lineages are CDKN3, OIP5, and NDUFC1. Each is linked with PLIN4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLIN4-to-partner and partner-to-PLIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN3 grouped by PLIN4-low versus PLIN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLIN4→partner) and Y-score (partner→PLIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDKN3 →	+0.635	+1.698	<.001	<.001	3	4
UCEC	OIP5 →	+0.654	+1.709	<.001	<.001	3	4
UCEC	NDUFC1 →	+0.316	+2.290	.001	<.001	3	4
UCEC	NCAPG →	+0.663	+2.010	<.001	.001	3	4
UCEC	COQ3 →	+0.400	+1.496	.001	.002	3	4
UCEC	TAF13 →	+0.481	+1.745	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,734 associations by consensus.

CDKN3 by PLIN4 expression — UCEC

Explore this box plot interactively →