PLIN4

Across TCGA pan-cancer cohorts, PLIN4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PLIN4 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PLIN4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PLIN4 expression acts as an unfavorable survival marker, although some lineages such as KIRP and BLCA show a favorable association.

KIRP, ACC, and UCEC are the cancer types where PLIN4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	II,III,IV	0.919	0.580	.001	82	view →
ACC	DFS	Median	All	0.266	0.636	<.001	64	view →
UCEC	OS	Median	All	0.514	0.794	.003	48	view →
BLCA	DFS	Quartile	All	0.448	0.272	.002	37	view →
OV	OS	Median	IV	0.562	0.929	<.001	34	view →
UCS	DFS	Median	III,IV	0.135	0.458	.012	34	view →
MESO	OS	Median	All	0.280	0.686	.003	33	view →
HNSC	DFS	Quartile	IV	0.484	0.213	.004	27	view →
BRCA	OS	Tertile	III,IV	0.896	0.725	<.001	26	view →
KIRC	DFS	Tertile	II,III,IV	0.468	0.645	.008	26	view →
READ	OS	Quartile	II,III,IV	0.820	1.000	.010	25	view →
THCA	DFS	Quartile	II,III,IV	0.566	0.946	.001	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PLIN4–KIRP (DFS)

Open the KIRP breakdown →