PLIN4

Across TCGA patient cohorts, PLIN4 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLIN4-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with PLIN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLIN4-to-partner and partner-to-PLIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PLIN4-low versus PLIN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLIN4→partner) and Y-score (partner→PLIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.620	-1.893	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.520	+2.584	.004	.010	3	3
UCEC	4E-BP1 →	+0.224	+2.807	.007	.002	3	3
SKCM	eIF4E →	+0.138	+2.000	.041	.029	3	2
SKCM	GAPDH →	+0.501	+2.087	.025	.005	3	2
COAD	GSK-3_pS9 →	-0.433	-3.169	.014	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ATM by PLIN4 expression — UCEC

Explore this box plot interactively →