PLGRKT

Across TCGA pan-cancer cohorts, PLGRKT Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PLGRKT data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PLGRKT Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PLGRKT expression acts as an unfavorable survival marker.

LUSC, SKCM, and BLCA are the cancer types where PLGRKT Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	III,IV	0.112	0.664	.003	12	view →
SKCM	OS	Median	All	0.179	0.781	<.001	11	view →
BLCA	DFS	Median	III,IV	0.122	0.572	.004	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PLGRKT–LUSC (OS)

Open the LUSC breakdown →