PLGRKT

Across TCGA pan-cancer cohorts, PLGRKT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PLGRKT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLGRKT RNA is repressed in tumor relative to normal tissue. In most cancer types PLGRKT is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, LIHC, and BRCA are the cancer types where PLGRKT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLGRKT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.783	<.001	11	view →
LIHC	Female	II,III,IV	+0.961	<.001	9	view →
BRCA	All	II,III,IV	+0.560	<.001	6	view →
LUAD	All	All	+0.494	<.001	6	view →
BLCA	Female	All	+0.370	.028	6	view →
KICH	All	All	−0.829	<.001	5	view →
CHOL	All	All	+1.315	<.001	4	view →
COAD	Female	All	−0.930	<.001	4	view →
LUSC	Male	III,IV	−0.757	.006	2	view →
READ	All	All	−0.625	.005	2	view →
ESCA	All	All	+0.557	.035	2	view →
HNSC	All	IV	+0.440	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PLGRKT–KIRC

Open the KIRC breakdown →