PLGRKT

Across TCGA patient cohorts, PLGRKT mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLGRKT-associated genes across cancer lineages are SEPTIN7P4, MIR548AW, and OR11H5P. Each is linked with PLGRKT in more than 1 cancer types. Because this analysis shows association rather than direction, both PLGRKT-to-partner and partner-to-PLGRKT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN7P4 grouped by PLGRKT-low versus PLGRKT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLGRKT→partner) and Y-score (partner→PLGRKT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SEPTIN7P4 →	+0.143	+5.970	<.001	.002	3	2
UCEC	MIR548AW →	+0.299	+4.245	<.001	.006	3	2
SKCM	OR11H5P →	+0.045	+5.362	<.001	.005	3	1
SKCM	GTF3AP2 →	+0.158	+5.037	<.001	.009	3	1
SKCM	MIR4688 →	+0.436	+5.224	<.001	.007	3	1
UCEC	MIR7702 →	+0.373	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

SEPTIN7P4 by PLGRKT expression — SKCM

Explore this box plot interactively →