PLGRKT

Across TCGA patient cohorts, PLGRKT mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLGRKT-associated genes across cancer lineages are Notch1, PDCD4, and PKC-delta_pS664. Each is linked with PLGRKT in more than 1 cancer types. Because this analysis shows association rather than direction, both PLGRKT-to-partner and partner-to-PLGRKT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PLGRKT-low versus PLGRKT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLGRKT→partner) and Y-score (partner→PLGRKT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.238	+2.820	.003	.035	3	1
UCEC	PDCD4 →	-0.805	-3.000	.003	.037	3	1
UCEC	PKC-delta_pS664 →	-0.195	-2.999	.004	.035	3	1
UCEC	CDK1 →	+0.215	+3.000	.014	.036	3	1
UCEC	GATA6 →	-0.239	-2.992	.007	.036	2	1
UCEC	eIF4E →	+0.255	+3.000	.037	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Notch1 by PLGRKT expression — UCEC

Explore this box plot interactively →