PLGLB2

Across TCGA cell cohorts, PLGLB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,823 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLGLB2-associated GO terms across cancer lineages are Regulation of alternative mRNA splicing, via spliceosome, Regulation of mRNA splicing, via spliceosome, and mRNA splice site recognition. Each is linked with PLGLB2 in more than 10 cancer types. Because this analysis shows association rather than direction, both PLGLB2-to-partner and partner-to-PLGLB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alternative mRNA splicing, via spliceosome grouped by PLGLB2-low versus PLGLB2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLGLB2→partner) and Y-score (partner→PLGLB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of alternative mRNA splicing, via spliceosome →	+0.069	+0.506	<.001	<.001	3	11
SKIN	Regulation of mRNA splicing, via spliceosome →	+0.070	+0.358	<.001	<.001	3	11
SKIN	mRNA splice site recognition →	+0.104	+0.397	<.001	<.001	3	11
SKIN	Termination of RNA polymerase II transcription →	+0.113	+0.467	<.001	<.001	3	10
OVARY	Regulation of translational initiation →	+0.082	+0.525	<.001	<.001	3	10
OVARY	Regulation of organelle assembly →	+0.043	+0.581	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,823 associations by consensus.

Regulation of alternative mRNA splicing, via spliceosome by PLGLB2 expression — BLOOD_Lymphoma

Explore this box plot interactively →