PLGLB2

Across TCGA pan-cancer cohorts, PLGLB2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PLGLB2 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PLGLB2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PLGLB2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

UVM, HNSC, and UCEC are the cancer types where PLGLB2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.336	0.750	.005	75	view →
HNSC	DFS	Median	IV	0.430	0.235	.001	62	view →
UCEC	DFS	Tertile	All	0.755	0.861	.002	48	view →
ACC	OS	Tertile	All	0.599	0.912	.006	25	view →
LUSC	DFS	Median	III,IV	0.174	0.851	<.001	18	view →
KIRP	OS	Tertile	IV	0.039	0.471	.010	18	view →
BRCA	DFS	Median	IV	0.756	0.323	.004	15	view →
LGG	DFS	Tertile	All	0.786	0.879	.006	14	view →
THYM	DFS	Tertile	III,IV	1.000	0.420	.015	13	view →
STAD	DFS	Median	IV	0.151	0.587	.003	13	view →
LUAD	DFS	Median	III,IV	0.728	0.553	.023	13	view →
TGCT	DFS	Tertile	II,III,IV	0.518	1.000	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PLGLB2–UVM (OS)

Open the UVM breakdown →