PLEKHO2

Across TCGA patient cohorts, PLEKHO2 mutation is significantly associated with the RNA expression of many other genes, with 1,154 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHO2-associated genes across cancer lineages are IGHV3-30, ZSWIM8-AS1, and RNU6-662P. Each is linked with PLEKHO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHO2-to-partner and partner-to-PLEKHO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHV3-30 grouped by PLEKHO2-low versus PLEKHO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHO2→partner) and Y-score (partner→PLEKHO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHV3-30 →	+1.896	+2.906	.004	.002	3	2
UCEC	ZSWIM8-AS1 →	+0.135	+3.613	.003	.001	3	2
LUAD	RNU6-662P →	+0.463	+5.217	<.001	.007	3	2
LUAD	RAB9AP4 →	+0.071	+7.333	<.001	<.001	3	2
LUAD	MIR6090 →	+0.729	+6.444	<.001	.001	3	2
LUAD	MIR6799 →	+0.469	+4.990	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,154 associations by consensus.

IGHV3-30 by PLEKHO2 expression — UCEC

Explore this box plot interactively →