PLEKHO1

Across TCGA cell cohorts, PLEKHO1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,636 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PLEKHO1-associated genes across cancer lineages are ICAM1, C3, and CAMK2N2. Each is linked with PLEKHO1 in more than 11 cancer types. Because this analysis shows association rather than direction, both PLEKHO1-to-partner and partner-to-PLEKHO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHO1 versus ICAM1 in BREAST, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHO1→partner) and Y-score (partner→PLEKHO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ICAM1 →	+3.286	+3.240	<.001	<.001	3	12
STOMACH	C3 →	+6.754	+5.190	<.001	.003	3	6
BLOOD_Lymphoma	CAMK2N2 →	+1.074	+1.343	.001	.007	3	6
BLOOD_Lymphoma	HAPLN3 →	+2.937	+2.480	<.001	<.001	3	5
BLOOD_Lymphoma	STX11 →	+3.145	+1.740	<.001	.001	3	4
OESOPHAGUS	DRAM1 →	+1.498	+3.468	.008	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,636 associations by consensus.

PLEKHO1 vs ICAM1 — BREAST

Explore this scatter interactively →