PLEKHM3

Across TCGA patient cohorts, PLEKHM3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,817 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEKHM3-associated genes across cancer lineages are DTD1, CYP4X1, and HOXD1. Each is linked with PLEKHM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHM3-to-partner and partner-to-PLEKHM3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHM3 versus DTD1 in PDAC, with a Pearson correlation of -0.94.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHM3→partner) and Y-score (partner→PLEKHM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	DTD1 →	-0.573	-0.339	.006	.006	3	2
PDAC	CYP4X1 →	+1.233	+0.260	<.001	.005	3	2
GBM	HOXD1 →	+0.285	+0.272	<.001	<.001	3	2
LSCC	MCC →	-0.636	-0.274	.001	.005	3	2
GBM	GPR62 →	+0.956	+0.272	<.001	<.001	3	2
LUAD	RUNX3-AS1 →	-0.635	-0.564	.007	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,817 associations by consensus.

PLEKHM3 vs DTD1 — PDAC

Explore this scatter interactively →