PLEKHM2

Across TCGA patient cohorts, PLEKHM2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,356 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHM2-associated genes across cancer lineages are PTH1R, IFFO1, and C1orf54. Each is linked with PLEKHM2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PLEKHM2-to-partner and partner-to-PLEKHM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHM2 versus PTH1R in BRCA, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHM2→partner) and Y-score (partner→PLEKHM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTH1R →	+1.043	+0.268	<.001	<.001	3	7
OV	IFFO1 →	+0.865	+0.261	<.001	<.001	3	6
UCEC	C1orf54 →	+0.882	+0.141	.002	<.001	3	6
OV	CNRIP1 →	+1.086	+0.354	<.001	<.001	3	6
OV	BICC1 →	+1.055	+0.259	.001	<.001	3	6
BRCA	PLXNC1 →	+0.962	+0.284	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,356 associations by consensus.

PLEKHM2 vs PTH1R — BRCA

Explore this scatter interactively →