PLEKHM2

Across TCGA pan-cancer cohorts, PLEKHM2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PLEKHM2 data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PLEKHM2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLEKHM2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and ESCA show a favorable association.

ACC, LUSC, and LIHC are the cancer types where PLEKHM2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.249	0.723	<.001	83	view →
LUSC	OS	Quartile	All	0.725	0.831	.001	70	view →
LIHC	DFS	Median	All	0.468	0.611	<.001	63	view →
BLCA	OS	Quartile	III,IV	0.209	0.524	.007	43	view →
LGG	OS	Median	All	0.381	0.518	<.001	37	view →
LAML	DFS	Median	All	0.361	0.544	.006	30	view →
OV	OS	Median	III,IV	0.281	0.351	.014	30	view →
UVM	DFS	Median	All	0.401	0.713	.007	23	view →
LUAD	OS	Tertile	II,III,IV	0.663	0.449	.004	18	view →
ESCA	DFS	Quartile	All	1.000	0.394	.009	16	view →
SCLC	DFS	Quartile	III,IV	0.667	0.192	.013	15	view →
CHOL	DFS	Tertile	All	0.707	0.154	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PLEKHM2–ACC (DFS)

Open the ACC breakdown →