PLEKHM2

Across TCGA patient cohorts, PLEKHM2 mutation is significantly associated with the RNA expression of many other genes, with 2,506 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHM2-associated genes across cancer lineages are KRTAP20-3, PHF5A, and PSMC3IP. Each is linked with PLEKHM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHM2-to-partner and partner-to-PLEKHM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP20-3 grouped by PLEKHM2-low versus PLEKHM2-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHM2→partner) and Y-score (partner→PLEKHM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	KRTAP20-3 →	+0.174	+7.977	<.001	.007	3	3
UCEC	PHF5A →	+0.462	+3.917	<.001	<.001	3	3
UCEC	PSMC3IP →	+0.614	+2.010	<.001	.001	3	3
COAD	RNU4-63P →	+0.284	+4.142	<.001	.006	3	3
UCEC	RPL23AP82 →	+0.448	+3.021	<.001	<.001	3	3
SKCM	RNU6-739P →	+0.101	+3.897	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,506 associations by consensus.

KRTAP20-3 by PLEKHM2 expression — LGG

Explore this box plot interactively →