PLEKHM2

Across TCGA patient cohorts, PLEKHM2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHM2-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and Caspase-8. Each is linked with PLEKHM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHM2-to-partner and partner-to-PLEKHM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PLEKHM2-low versus PLEKHM2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHM2→partner) and Y-score (partner→PLEKHM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.431	+2.824	<.001	.034	3	3
UCEC	ATM →	-0.450	-1.906	.013	.016	3	2
UCEC	Caspase-8 →	-0.303	-3.558	.002	.002	3	2
COAD	eIF4E →	+0.300	+2.820	.001	.035	2	2
COAD	CDK1 →	+0.308	+3.008	.001	.019	3	1
COAD	Cyclin-E1 →	+0.259	+3.008	.046	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Caspase-7-cleavedD198 by PLEKHM2 expression — COAD

Explore this box plot interactively →