PLEKHM2

Across TCGA cell cohorts, PLEKHM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,279 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHM2-associated GO terms across cancer lineages are Negative regulation of autophagy, Positive regulation of autophagy, and Regulation of pattern recognition receptor signaling pathway. Each is linked with PLEKHM2 in more than 16 cancer types. Because this analysis shows association rather than direction, both PLEKHM2-to-partner and partner-to-PLEKHM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of autophagy grouped by PLEKHM2-low versus PLEKHM2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHM2→partner) and Y-score (partner→PLEKHM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of autophagy →	+0.110	+1.006	<.001	<.001	3	17
STOMACH	Positive regulation of autophagy →	+0.080	+1.221	<.001	<.001	3	16
LARGE_INTESTINE	Regulation of pattern recognition receptor signaling pathway →	+0.061	+1.149	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Negative regulation of organelle assembly →	+0.086	+1.118	.005	<.001	2	17
STOMACH	Positive regulation of autophagy of mitochondrion →	+0.105	+1.020	<.001	<.001	3	15
BREAST	Response to methionine →	+0.129	+1.066	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,279 associations by consensus.

Negative regulation of autophagy by PLEKHM2 expression — STOMACH

Explore this box plot interactively →