PLEKHM2

Across TCGA cell cohorts, PLEKHM2 mutation is significantly associated with the RNA expression of many other genes, with 283 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHM2-associated genes across cancer lineages are DDHD1, ACOT8, and CCP110. Each is linked with PLEKHM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHM2-to-partner and partner-to-PLEKHM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDHD1 grouped by PLEKHM2-low versus PLEKHM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHM2→partner) and Y-score (partner→PLEKHM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DDHD1 →	+0.864	+3.364	<.001	.002	3	1
LARGE_INTESTINE	ACOT8 →	-0.786	-3.278	<.001	.006	3	1
LARGE_INTESTINE	CCP110 →	+0.613	+3.364	.009	.002	3	1
LARGE_INTESTINE	FZD3 →	+0.725	+3.364	.004	.002	3	1
LARGE_INTESTINE	TRIM37 →	+0.667	+3.364	.001	.002	3	1
LARGE_INTESTINE	USP46 →	+0.683	+3.451	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 283 associations by consensus.

DDHD1 by PLEKHM2 expression — LARGE_INTESTINE

Explore this box plot interactively →