Across TCGA patient cohorts, PLEKHM1 mutation is significantly associated with the RNA expression of many other genes, with 5,373 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHM1-associated genes across cancer lineages are DGCR11, C18orf25, and PPP2R5E. Each is linked with PLEKHM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHM1-to-partner and partner-to-PLEKHM1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHM1→partner) and Y-score (partner→PLEKHM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DGCR11 →	+0.360	+2.695	.001	<.001	3	3
COAD	C18orf25 →	+0.554	+3.486	<.001	.002	3	3
UCEC	PPP2R5E →	+0.441	+3.108	<.001	<.001	3	3
COAD	ARL13B →	+0.530	+3.526	.005	.002	3	3
COAD	CNTROB →	+0.510	+3.210	.001	.009	3	3
UCEC	MANEA →	+0.439	+1.660	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,373 associations by consensus.

Exploration

PLEKHM1 survival (RNA) · tumor vs normal (RNA) · all PLEKHM1 data types