PLEKHH1

Across TCGA patient cohorts, PLEKHH1 mutation is significantly associated with the RNA expression of many other genes, with 5,000 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHH1-associated genes across cancer lineages are RNU4-58P, TRIM36, and SKA1. Each is linked with PLEKHH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLEKHH1-to-partner and partner-to-PLEKHH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by PLEKHH1-low versus PLEKHH1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHH1→partner) and Y-score (partner→PLEKHH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU4-58P →	+0.168	+4.564	<.001	.003	3	4
UCEC	TRIM36 →	+1.011	+1.954	<.001	<.001	3	3
UCEC	SKA1 →	+0.812	+3.140	<.001	<.001	3	3
UCEC	SLC13A3 →	-0.418	-2.054	.003	.001	3	3
UCEC	TBC1D24 →	+0.308	+2.202	.001	.001	3	3
UCEC	AZI2 →	+0.492	+2.736	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,000 associations by consensus.

RNU4-58P by PLEKHH1 expression — COAD

Explore this box plot interactively →