Across TCGA patient cohorts, PLEKHG7 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG7-associated genes across cancer lineages are EGFR_pY1068, EGFR, and ERK2. Each is linked with PLEKHG7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHG7-to-partner and partner-to-PLEKHG7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG7→partner) and Y-score (partner→PLEKHG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.318	-3.087	.001	<.001	3	1
UCEC	EGFR →	-0.207	-3.584	.001	.002	3	1
UCEC	ERK2 →	+0.267	+2.584	<.001	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.203	+1.920	.014	.009	3	1
UCEC	Notch1 →	+0.165	+2.335	.003	.018	3	1
UCEC	p62 Lck ligand →	+0.343	+3.087	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

PLEKHG7 survival (RNA) · tumor vs normal (RNA) · all PLEKHG7 data types